The 8 Best Supplements to Support Healthy Cholesterol Levels

Cholesterol, a substance crucial for proper body function, becomes a health risk when levels rise too high, potentially leading to heart disease and hypertension.

Many individuals turn to targeted supplements to proactively manage these levels and bolster overall cardiovascular health.

Choosing the best option requires understanding key ingredients like plant sterols, soluble fiber, or omega-3 fatty acids, which interact differently with the body’s systems.

To simplify your search for effective heart support, we have compiled the definitive list of top cholesterol supplements available today, researched and tested to ensure you find a quality product designed to support healthy lipid metabolism.

1. 1MD Nutrition CholestMD Supports Healthy Cholesterol Levels

This doctor-formulated supplement offers a comprehensive approach to heart and circulatory health. Key components include Bergavit, a powerful extract derived from bergamot juice, which actively promotes robust circulatory function.

Additionally, the formula incorporates Niacin, a B vitamin known for its role in maintaining optimal triglyceride levels, thus supporting overall cardiovascular and brain function.

CholestMD is specifically designed to support cholesterol levels that are already within a normal, healthy range, and it also aids in the maintenance of healthy blood pressure.

Users looking for multi-faceted support for their lipid profile will find this formula appealing, although individual results concerning effectiveness may vary.

Best For: Individuals seeking doctor-formulated, multi-action cardiovascular support.

Pros

• Supports normal cholesterol levels already.
• Promotes strong circulatory function, heart health.
• Helps maintain healthy triglyceride levels.
• Contains vital, powerful Bergavit extract.
• Supports optimal blood pressure maintenance.

Cons

• Some users report potential joint discomfort.
• Individual effectiveness can greatly vary.
• Not suited for certain medical conditions.

2. UpNourish Citrus Bergamot Cholesterol Supplement

UpNourish provides a natural and potent approach to regulating lipid metabolism, focusing heavily on cholesterol and triglyceride balance.

This formula utilizes an impressive synergy of natural compounds, including BERGAVIT citrus bergamot extract, plant sterols, CoQ10, fish oil omega-3, turmeric curcuminoids, olive leaf, and garlic extract.

This combination delivers vital nutrients supporting circulation and artery health. Crucially, this supplement works by regulating both how the body synthesizes cholesterol internally (endogenous) and how it absorbs cholesterol from food (exogenous). This is a high-quality product, proudly GMO-free and organic.

Best For: Consumers seeking comprehensive, organic lipid support involving multiple natural extracts.

Pros

• Extensive combination of potent natural ingredients.
• Supports healthy lipid metabolism effectively.
• Promotes robust circulation and artery health.
• Helps optimize blood pressure management.
• GMO-free, certified organic formulation.

Cons

• Mild stomach upset or headaches possible.
• Requires consistency for long-term results.
• Potential interaction with prescription drugs.

3. Garlique Garlic Extract Supplement

Garlique is an excellent choice for individuals prioritizing cardiovascular wellness using the time-tested power of garlic.

Each convenient caplet is standardized to contain 5,000 mcg of allicin, which is the active compound in garlic recognized for its heart health benefits.

A major advantage of this supplement is its ease of use; it is designed to be completely odor-free and taste-free, allowing users to gain the benefits of garlic without the typical unpleasant aftertaste or aroma.

Furthermore, Garlique provides reliability through independent lab testing and verification, ensuring that the allicin yield and potency are optimal in every single caplet.

Best For: Individuals seeking the cardiovascular benefits of garlic without odor or taste issues.

Pros

• Verified potency of 5,000 mcg allicin.
• Completely odor-free and taste-free delivery.
• Convenient and extremely easy to swallow.
• Supports vital heart health function.
• Lab-verified for purity and optimal yield.

Cons

• May cause mild gas or bloating.
• Higher price point than some options.
• Must be careful with blood thinners.

4. Nature Made CholestOff Complete

Nature Made CholestOff Complete is a compelling option for those committed to lowering dietary cholesterol and supporting comprehensive heart function.

This formula features Pantesin, an ingredient scientifically shown to reduce the production of undesirable LDL cholesterol within the liver.

A significant assurance of quality is its verification by the United States Pharmacopeia (USP), confirming that the product meets high standards for purity and potency.

Manufactured in the USA, it utilizes quality ingredients sourced globally. While highly effective at reducing cholesterol levels, prospective users must be aware of the intensive dosing schedule, requiring three softgels taken twice daily with meals.

Best For: Serious users prioritizing USP-verified quality and focused LDL production reduction.

Pros

• Pantesin reduces harmful LDL production.
• Exceptional quality, USP verification achieved.
• Supports overall heart health effectively.
• Uses quality global ingredients.
• Reliable reduction in cholesterol levels.

Cons

• Expensive compared to competitors.
• Strict dosing schedule required daily.
• Non-vegan; contains animal ingredients.

5. Dr. Sinatra Advanced Cholesterol Solutions Heart Health Supplement

Formulated by the renowned integrative cardiologist Stephen Sinatra, M.D., this supplement is a trusted natural solution for maintaining healthy cholesterol levels.

The core of this revolutionary formula is Bergamonte, an extract sourced from the citrus bergamot orange.

Bergamonte excels at promoting healthy lipid balance by not only supporting normal levels of LDL and triglycerides but also crucially boosting the levels of HDL, the “good” cholesterol.

Furthermore, this ingredient provides valuable support for maintaining blood vessel health. The product guarantees high quality, safety, and purity, as it is manufactured in the USA from globally sourced ingredients and triple-tested.

Best For: Individuals valuing cardiologist-developed formulas targeting HDL, LDL, and triglycerides simultaneously.

Pros

• Developed by leading clinical cardiologist.
• Bergamonte boosts beneficial HDL cholesterol.
• Supports normal blood vessel function.
• Rigorous triple testing assures high purity.
• Helps manage triglycerides naturally.

Cons

• Full lipid results may take 90 days.
• The orange flavor is disliked by some.
• Not recommended for pregnant women.

6. Thorne Choleast-900-900mg Red Yeast Rice Extract

Thorne Choleast-900 offers a natural extract utilizing Red Yeast Rice (RYR) to effectively support and maintain healthy cholesterol levels.

Red yeast rice naturally contains several beneficial compounds, including phytosterols, isoflavones, and naturally occurring monacolins, which collectively help promote healthy lipid levels and optimize particle size.

Thorne is recognized as a trusted brand, known for its history of collaboration with major health institutions and athletic organizations, lending credibility to its formulation.

While this supplement provides a solid, natural option for lipid support, users should understand that results concerning significant cholesterol reduction may be mixed depending on individual physiological factors. It is crucial to consult a healthcare provider before use due to potential drug interactions.

Best For: Consumers seeking lipid support from a highly trusted, natural Red Yeast Rice brand.

Pros

• Red yeast rice naturally maintains healthy lipids.
• Contains beneficial monacolins and phytosterols.
• Backed by a highly trusted brand history.
• Gluten-free and verified non-GMO.
• Supports healthy particle size optimization.

Cons

• Effectiveness varies among some users.
• Contains soy; allergen concern for some.
• Requires consultation due to drug interaction.

7. GriMed Citrus Bergamot Supplement

GriMed’s formula is an advanced, natural approach to improving cholesterol and overall health, distinguished by its potent complexity.

It boasts a powerful combination of ten beneficial herbs, including Niacin, Red Yeast Rice, Artichoke, Berberine, and Psyllium, alongside its primary concentrated extract of Citrus Bergamot (a high 50:1 ratio).

This scientifically developed formula utilizes precise proportions of ingredients to maximize quality and effectiveness. Rigorous testing by third-party ISO 17025-accredited labs ensures the purity and safety of all components.

Furthermore, this is a clean supplement, being 100% natural, and free from gluten, sugar, GMOs, and artificial colors. Each bottle conveniently lasts for five months.

Best For: Individuals wanting a comprehensive, potent, 10-herb blend with accredited third-party quality testing.

Pros

• Potent 50:1 concentrated Bergamot extract.
• Powerful blend of ten beneficial herbs.
• Third-party lab tested for verifiable safety.
• Completely natural, sugar and gluten-free.
• Backed by strong money-back guarantee.

Cons

• Higher cost compared to basic options.
• Potential for allergic or stomach reactions.
• Effectiveness may not be universal.

8. NOW Cholesterol Pro™ with Bergamonte™ and Plant Sterols

NOW Cholesterol Pro™ is an excellent maintenance choice for supporting existing healthy lipid profiles. This supplement features a synergistic blend of Bergamonte™ and beneficial Plant Sterols.

Clinical data supports this combination, demonstrating its ability to maintain serum lipid levels already within the healthy range while promoting overall cardiovascular health.

As an inclusive option, the formula is committed to purity standards: it is soy-free, non-GMO, and entirely vegan-friendly.

Furthermore, consumers benefit from the assurance that this product adheres to GMP (Good Manufacturing Practice) Quality Assured standards. This product is best suited for ongoing maintenance as part of a comprehensive approach to heart health.

Best For: Vegans and individuals focused on maintaining already healthy cholesterol levels with clinical support.

Pros

• Clinically shown to support serum lipid levels.
• Excellent, reliable vegan formulation.
• Adheres to strict GMP quality standards.
• Synergistic Bergamonte/Plant Sterol blend.
• Supports strong overall cardiovascular health.

Cons

• Requires consistent use to observe changes.
• Not ideal for severe cholesterol problems.
• Natural color variations may occur.