Oxytocin is often called the feel good or bonding hormone because of its powerful role in promoting emotional balance, relaxation, and positive social connection.
Many people look for oxytocin supplements to help reduce stress, improve mood, and support a calmer state of mind in today’s fast paced lifestyle.
These supplements are usually designed to support natural oxytocin release through carefully selected ingredients like amino acids, herbs, and adaptogens.
In this guide, we explore the top 10 best oxytocin supplements that may help enhance mood, encourage relaxation, and support overall emotional well being in a safe and convenient way.
10. OxyNaturals OxyBoost Nitric Oxide Supplement
OxyNaturals OxyBoost Nitric Oxide Supplement delivers a natural, L‑arginine‑free formula designed to keep your circulatory system running smoothly.
Each capsule contains the patented Vinitrox blend, which stimulates the body’s own nitric oxide production, helping blood flow more efficiently to the heart, brain, and extremities.
The result is better oxygen delivery, supporting cardiovascular health, stable blood pressure, and healthy vessel dilation.
Because the boost comes from enhanced circulation rather than caffeine or stimulants, you’ll notice a steady rise in energy and stamina that lasts throughout the day.
Improved blood flow to the brain also aids mental clarity, focus, and reduces the fog that can slow you down.
The supplement is non‑GMO, gluten‑free, and packaged in a convenient 3‑month supply—180 capsules across three bottles—so you can maintain consistent support for heart health, energy, and cognition without frequent refills.
Pros
- Enhances nitric oxide for optimal circulation
- Natural energy boost without caffeine or stimulants
- Supports mental clarity and focus daily
- L‑arginine‑free, reducing side‑effect risk
- Non‑GMO, gluten‑free, vegan‑friendly formula
Cons
- May take a few weeks for full effect
- Not a substitute for prescribed heart medication
- Requires consistent daily intake for best results
9. Pink Stork Total Lactation Supplement
Pink Stork Total Lactation Supplement blends five organic, clinically‑backed galactagogues—Fenugreek, Alfalfa, Blessed Thistle, Milk Thistle, and Fennel—into two small capsules a day.
The formula is designed to support prolactin and oxytocin production, soothe gassy or colicky babies through breast‑milk, and provide a rich mix of vitamins, minerals, amino acids, and antioxidants for balanced energy.
No preparation or messy lactation snacks are required; each bottle supplies a full month’s worth and fits easily into a post‑natal vitamin routine or a pumping bag at work.
Developed by a female team of experts, the capsules are third‑party tested and contain no gluten, dairy, peanuts, or GMOs.
Founder Amy Suzanne, a mom of six, ensures the brand reflects real‑world motherhood, with over 80 % of staff being women. Pink Stork’s mission is to give new moms trustworthy, clean products that boost confidence and nurture the breastfeeding journey.
Pros
- Supports breast milk production and flow naturally
- Organic, herbal ingredients blend
- Easy, daily capsule format
- Free from gluten, dairy, peanuts, and GMOs
- Can complement pumping and breastfeeding routines
Cons
- Mixed effectiveness for some users
- Herbal scent or taste might not suit everyone
- Results may take time to appear
8. Supersmart Lactobacillus Reuteri Probiotic 60 Capsules
Supersmart’s Lactobacillus Reuteri probiotic delivers 5 billion CFU per day in gastro‑resistant, delayed‑release capsules.
The next‑generation L. reuteri strain supports a balanced intestinal microflora and promotes bile‑salt‑hydrolase (BSH) enzyme activity, which can aid digestion and nutrient absorption.
Each bottle contains 60 vegetarian DR capsules, formulated with a non‑GMO, gluten‑free blend of hypromellose (vegetable) capsule, acacia gum, and white rice flour—no synthetic coatings.
For optimal potency, store the capsules refrigerated. Recommended use is two capsules daily, providing a steady release of live microorganisms throughout the gut.
Supersmart backs every purchase with 24/7 customer service and a 100 % satisfaction guarantee, a promise they’ve upheld since 1992.
Pros
- Delayed‑release caps for targeted gut delivery
- High‑potency 5 B CFU L. reuteri strain
- Non‑GMO, gluten‑free, fully vegetarian formula
- Supports intestinal microflora and BSH enzymes
- 24/7 support with lifetime satisfaction guarantee
Cons
- Requires refrigeration for best stability
- May be pricier than standard probiotics
- Limited to two capsules per day dosage
7. Toniiq Lactobacillus Reuteri Probiotic
Toniiq’s Lactobacillus Reuteri probiotic delivers a powerhouse 50 billion CFU per serving, making it one of the highest‑verified counts available.
Each vegetarian capsule is packed with a clinically studied strain that’s renowned for supporting gut balance, immune health, and overall digestion.
The formula is manufactured in a GMP‑certified, state‑of‑the‑art facility in the USA, where every batch undergoes rigorous in‑house and third‑party laboratory testing. This dual‑testing protocol guarantees purity, potency, and freedom from unwanted additives, contaminants, or impurities.
Whether you’re looking to reinforce your daily gut health routine or need a reliable probiotic boost, Toniiq’s L Reuteri offers consistent, science‑backed performance you can trust.
Pros
- 50 Billion CFU per serving, industry‑leading potency
- Clinically researched L Reuteri strain supports digestion
- GMP‑certified US manufacturing ensures high standards
- Dual in‑house and third‑party batch testing guarantees purity
- Vegetarian capsules suitable for most dietary preferences
Cons
- Higher price point than basic probiotics
- Requires daily intake for optimal results
- May cause mild gas during initial adjustment
6. Jarrow Formulas Fem-Dophilus Probiotics
Jarrow Formulas Fem‑Dophilus Vaginal Probiotics delivers a clinically‑backed, 1 billion CFU daily dose that’s specifically formulated for women’s intimate health.
Each capsule contains Lactobacillus rhamnosus GR‑1 and Lactobacillus reuteri RC‑14, the two probiotic strains with the strongest research record for supporting a balanced vaginal microbiome and a healthy urinary tract.
The bacteria are protected by a patented manufacturing process that shields them from stomach acid, allowing the live cultures to reach the lower intestine and then the vaginal environment where they can colonize effectively.
The formula is vegan, Non‑GMO Project Verified, gluten‑free, and comes in an ActivVial moisture‑controlled desiccant bottle, so the probiotics stay stable without refrigeration.
With 60 capsules, you have a 60‑day supply that fits seamlessly into a daily routine, and the shelf‑stable design makes travel and storage hassle‑free.
Jarrow’s commitment to “superior science, smarter formulas” means each ingredient is chosen for maximum potency and bioavailability, backed by over three decades of clinical research.
Pros
- Clinically proven strains for vaginal health
- Acid‑resistant delivery protects live bacteria
- Shelf‑stable, no refrigeration required
- Vegan, Non‑GMO, gluten‑free formulation
- 60‑day supply in moisture‑controlled bottle
Cons
- Only 1 billion CFU per capsule
- May be pricier than generic probiotics
- Requires consistent daily intake for best results
5. Oxygen America Super OxyFlush Capsules
Oxygen America’s Super OxyFlush Colon Cleanser delivers a gentle, oxygen‑activated detox that’s perfect for anyone looking to support regular bowel movements without harsh chemicals.
Each capsule contains pharmaceutical‑grade, ozonated magnesium oxide, a proven, non‑GMO ingredient that works to break down waste, reduce bloating, and promote overall gut balance.
The formula is allergen‑free and free from artificial fillers, making it a safe choice for both men and women seeking natural constipation relief.
By delivering magnesium in an oxygen‑powered matrix, Super OxyFlush helps the colon clear buildup efficiently while maintaining comfort, so you can feel lighter, more energized, and ready to take on the day.
Pros
- Gentle, oxygen‑activated detox for daily use
- Supports regular bowel movements naturally
- Reduces bloating and abdominal discomfort quickly
- Allergen‑free, non‑GMO, pharmaceutical‑grade magnesium
- Boosts energy by improving waste elimination
Cons
- May require consistent use for best results
- Not a substitute for medical treatment
- Capsules size may be large for some users
4. Novex Biotech Oxydrene NAD+ Enhancer
Oxydrene NAD+ Enhancer from Novex Biotech is a natural, capsule‑based supplement crafted to boost your body’s own production of the vital NAD+ coenzyme. As we age, NAD+ levels can fall by up to 90 %, leading to reduced stamina, fuzzy focus, and weaker cardiovascular function.
This proprietary blend supplies the nutrients your cells need to restore NAD+ quickly—often within an hour—so you feel sharper, more energetic, and ready for peak performance.
Each serving delivers a fast‑acting, GMP‑certured formula that supports endurance, mental clarity, and heart health without synthetic stimulants. And because Novex stands behind its products, you receive a straightforward money‑back guarantee if you’re not satisfied.
Pros
- Boosts energy and endurance for peak performance
- Helps restore age‑related NAD+ decline quickly
- Supports cardiovascular health naturally
- Fast‑acting effect noticeable within one hour
- GMP‑certified, money‑back guarantee included
Cons
- Requires daily capsule intake for best results
- May interact with certain prescription medications
- Not a substitute for medical treatment of heart conditions
3. QUBIT Oxaloacetate Capsules
QUBIT Oxaloacetate Supplement (60 Capsules) delivers a clinically researched blend of thermally stabilized oxaloacetate and Vitamin C in a vegan, non‑GMO capsule.
By supporting mitochondrial ATP production, it helps counter the average American’s 1,460 hours of annual fatigue, keeping you sharp and energized.
The 150 mg dose also promotes emotional balance during PMS, with 80 % of women in a user survey reporting reduced irritability and a calmer mood.
Oxaloacetate’s neuro‑protective action reduces oxidative stress, improving mental clarity, focus, and memory when brain fog strikes.
Additionally, the formula activates longevity pathways that may extend cellular lifespan by up to 25 %, helping replenish declining NAD⁺ levels as you age.
Free from gluten, GMOs, and artificial additives, this supplement is trusted by health professionals for purity and effectiveness.
Pros
- Boosts ATP production for sustained daily energy
- Eases PMS mood swings and irritability naturally
- Enhances mental clarity, focus, and memory recall
- Activates longevity genes for healthier aging cells
- Vegan, non‑GMO capsule with added Vitamin C
Cons
- May cause mild digestive upset
- Not a substitute for medical treatment
- Effects vary; results may take weeks to appear
2. OxyEnergy NAD Day Supplement
OxyEnergy NAD Supplement delivers a full‑day, dual‑phase boost for your cells. Each morning packet packs 850 mg of nicotinamide riboside (NR) together with green‑tea extract and PQQ, jump‑starting mitochondrial ATP production and fortifying antioxidant defenses against oxidative stress.
When the sun sets, the evening stick supplies 700 mg of L‑tryptophan, resveratrol, ergothioneine and spermidine to kick‑start NAD⁺ regeneration, support deeper restorative sleep, and trigger autophagy‑driven cellular cleanup.
NAD⁺ naturally drops up to 65 % between ages 30‑70, a key driver of fatigue, skin aging, and metabolic slowdown. OxyEnergy’s patented blend fuels the “golden” self‑renewal cycle—clinical data show a 51 % rise in NAD⁺ levels after just two weeks.
The formula is flavored with zesty orange for the AM and sweet berries for the PM, mixes easily into water, and is free from gluten, dairy, and nuts. Produced in GMP‑certified facilities and third‑party tested, every packet guarantees purity and potency for 24‑hour anti‑aging support.
Pros
- All‑day NAD⁺ support, day & night
- Boosts mitochondrial energy and antioxidant defense
- Enhances sleep quality and cellular repair
- Promotes autophagy for senescent‑cell clearance
- Gluten‑, dairy‑, nut‑free, great taste
Cons
- Requires two packets daily
- May cause mild digestive adjustment
- Not suitable for pregnant or nursing individuals without doctor approval
1. BLIVA Lactobacillus Reuteri 50B CFU Capsules
BLIVA Lactobacillus Reuteri Capsules deliver a clinically‑backed, ultra‑concentrated probiotic blend that supports digestive balance, immune resilience, and overall vitality.
Each serving packs 50 billion CFU of Lactobacillus reuteri—one of the highest counts on the market—ensuring a potent dose in just two capsules per day.
The formula is non‑GMO, gluten‑free, additive‑free, and filler‑free, and the vegan‑friendly capsules are made from vegetable cellulose, making them suitable for a wide range of dietary lifestyles.
Every batch undergoes strict quality testing for purity and potency, reflecting BLIVA Nutrition’s commitment to premium, American‑manufactured supplements.
With 90 capsules per bottle, you get a convenient 45‑day supply that fits seamlessly into daily routines while promoting gut health and immune function.
Pros
- Highest CFU count for maximum potency
- Ultra‑concentrated L. reuteri per capsule
- Vegan‑friendly, vegetable‑cellulose capsule design
- Non‑GMO, gluten‑free, no fillers or additives
- Trusted American brand with rigorous quality checks
Cons
- Requires two capsules daily for full dose
- May be pricey compared to lower‑CFU probiotics
- Not suitable for those avoiding all bacterial supplements
Frequently Asked Questions
What should I look for when choosing the best oxytocin supplement?
- Purity and quality – Choose products that are third‑party tested for contaminants and contain the advertised amount of oxytocin.
- Formulation – Most effective supplements use a sublingual or nasal spray delivery to bypass digestion, as oxytocin is a peptide that can be broken down in the stomach.
- Dosage clarity – Look for clear labeling of IU (International Units) per dose and recommended usage guidelines.
- Reputable brand – Opt for manufacturers with good reviews, transparent sourcing, and GMP (Good Manufacturing Practice) certification.
How long does it take to notice the effects of an oxytocin supplement?
- Onset – When taken sublingually or as a nasal spray, many users report feeling a subtle mood lift within 15–30 minutes.
- Consistency – Full benefits, such as improved social bonding or reduced anxiety, typically emerge after daily use for 1–2 weeks.
- Individual variation – Factors like body weight, baseline oxytocin levels, and overall health can influence timing, so results may vary from person to person.
Are there any safety concerns or side effects I should be aware of?
- Common mild effects – Drowsiness, lightheadedness, or a warm sensation at the site of administration are occasionally reported.
- Contraindications – People with hormonal disorders, pregnancy, breastfeeding, or those on certain psychiatric medications should consult a healthcare professional before use.
- Dosage limits – Stick to the manufacturer’s recommended dose; excessive intake can lead to hormonal imbalances or interfere with blood pressure regulation.
- Long‑term data – Research on chronic oxytocin supplementation is still limited, so periodic health check‑ups are advisable if you plan extended use.
Conclusion
Choosing an oxytocin supplement wisely hinges on understanding both its potential benefits and the nuances that differentiate quality products.
Prioritize formulations that are third‑party tested, contain clinically supported dosages, and use bioavailable delivery methods to ensure consistent absorption.
Remember that individual responses can vary, so starting with a low dose and monitoring effects is prudent, especially if you have underlying health conditions or are taking other medications.
By focusing on reputable brands, transparent ingredient lists, and evidence‑based dosing, you can harness oxytocin’s mood‑enhancing and social‑bonding properties safely, making it a valuable addition to a holistic wellness routine.
