St Johns Wort supplements are widely used for supporting mood balance, emotional wellbeing, and overall mental health. Derived from the flowering plant Hypericum perforatum, this natural herb has a long history in traditional medicine.
Today, it is commonly chosen by people looking for a plant based option to help manage mild stress, low mood, and nervous tension. With many brands offering different formulas, strengths, and added ingredients, choosing the right supplement can feel confusing.
This guide to the Top 10 Best St Johns Wort Supplements highlights trusted options that focus on quality, purity, and effectiveness to help you make an informed decision.
10. Oregon’s Wild Harvest St John’s Wort 90 Count
Oregon’s Wild Harvest St John’s Wort Supplement offers a gentle, plant‑based boost for those days when your mood could use a lift.
Each capsule delivers pure, sustainably sourced St John’s Wort, verified non‑GMO by SGS, ensuring you receive a clean, high‑quality product without any artificial flavors, colors, excipients, or stearates.
Made with love in Redmond, OR, every batch reflects the brand’s commitment to transparency and local craftsmanship.
Whether you’re navigating a busy workweek or simply looking for everyday emotional balance, this 90‑count bottle provides consistent, natural support to help you feel steadier and more upbeat.
Pros
- Natural mood support without synthetic additives
- Non‑GMO verified by an independent lab
- Free of artificial flavors, colors, and excipients
- Made locally in Redmond, Oregon with care
- Convenient 90‑capsule bottle for daily use
Cons
- May interact with certain medications
- Not a substitute for professional mental‑health care
- Effects can vary between individuals
9. Horbäach St John’s Wort 300mg Capsules
Horbäach St John’s Wort Capsules deliver a potent, plant‑based boost in a convenient 300 mg quick‑release capsule. Each dose harnesses the bright yellow blossoms of St. John’s Wort, a herb celebrated for centuries in traditional wellness routines.
Our advanced formula is laboratory‑tested and crafted with a strict non‑GMO, gluten‑free standard, ensuring you receive pure, potent ingredients without wheat, yeast, milk, lactose, artificial flavors, sweeteners, or preservatives.
The 120‑count bottle provides a month’s supply of reliable support, backed by Horbäach’s commitment to superior quality and a 100 % satisfaction guarantee.
Whether you’re looking to maintain a balanced mood or simply add a trusted herbal ally to your daily regimen, these capsules combine heritage wisdom with modern manufacturing excellence.
Pros
- High‑potency 300 mg St John’s Wort dose
- Quick‑release capsules for fast absorption
- Non‑GMO, gluten‑free, allergen‑free formula
- Lab‑tested ingredients guarantee purity
- Backed by 100 % satisfaction guarantee
Cons
- Not suitable for individuals on antidepressants
- May cause photosensitivity in sensitive users
- Requires consistent daily intake for best results
8. NOW Foods St. John’s Wort 300 mg
NOW Foods St. John’s Wort delivers a potent, standardized 0.3 % hypericin extract in 250 vegan capsules. Each dose provides 300 mg of the herb, a formula rooted in more than 2,000 years of traditional use.
The capsules are Non‑GMO Project Verified, Kosher, Soy‑free, Nut‑free, Gluten‑free, Dairy‑free, and Egg‑free, making them suitable for a wide range of dietary preferences.
Manufactured in a GMP‑certified facility (NPA A‑rated), every batch undergoes rigorous testing for stability, potency, and purity.
Packaged in the USA by a family‑owned company that’s been operating since 1968, you can trust the quality and consistency of each bottle. For best results, take one capsule three times daily with food.
Pros
- Standardized 0.3 % hypericin ensures consistency
- Vegan capsules meet plant‑based lifestyle needs
- Non‑GMO Project verified for clean sourcing
- GMP‑certified production guarantees potency and safety
- Free from common allergens: gluten, dairy, soy
Cons
- Requires three capsules per day
- May interact with certain medications
- Not suitable for pregnant or nursing individuals without doctor’s advice
7. Nutricost St John’s Wort Capsules 500mg
Nutricost’s St John’s Wort capsules deliver a potent, pure dose of this time‑tested herb in a convenient, vegetarian format. Each bottle contains 120 capsules, each packed with 500 mg of standardized St John’s Wort, ensuring consistent potency from the first dose to the last.
The formula is straightforward—St John’s Wort is the only active ingredient, so you get the full benefits without fillers or unnecessary additives.
Nutricost has taken extra steps to keep the product clean and trustworthy: it’s non‑GMO, gluten‑free, soy‑free, and vegetarian‑friendly, and every batch undergoes third‑party testing for purity and potency.
Manufactured in a GMP‑compliant, FDA‑registered facility, the capsules meet rigorous quality standards, giving you confidence in every capsule you take.
Pros
- High‑strength 500 mg dose per capsule
- 120 vegetarian capsules per bottle, great value
- Only St John’s Wort, no filler ingredients
- Non‑GMO, gluten‑free, soy‑free formulation
- Third‑party tested for purity and potency
Cons
- May interact with certain medications
- Not suitable for pregnant or nursing women
- Requires consistent daily intake for best results
6. St John’s Wort Capsules 120
St. John’s Wort Capsules deliver a high‑potency, whole‑herb complex that’s been trusted for centuries. Each vegan capsule is standardized to 900 µg of hypericin (0.3 %), the active compound known for supporting a balanced mood.
The formula is pure‑plant, non‑GMO, and lab‑verified for potency and safety. With one capsule per serving and 120 capsules per bottle, you get a simple, mess‑free routine—no bitter tinctures, no gritty powders.
Produced in a GMP‑certified U.S. facility using globally sourced ingredients, the capsules contain only St. John’s Wort and a neutral carrier, ensuring what’s on the label is exactly what you receive every time.
Pros
- Potent 900 µg hypericin per serving
- Vegan, non‑GMO, and lab‑verified formula
- One‑capsule daily dose, hassle‑free
- GMP‑certified U.S. manufacturing standards
- 120‑capsule bottle provides long‑term supply
Cons
- May interact with certain medications
- Not a substitute for professional mental‑health care
- Slightly higher price than generic brands
5. Wild Organic St Johns Wort Tincture
Wild & Organic’s St John’s Wort tincture delivers a potent, plant‑based mood boost in a gentle, alcohol‑free liquid. Each serving packs 685 mg of pure St John’s Wort herb, known for its calming and uplifting properties, making it an ideal daily companion for stress‑prone lifestyles.
The formula is 100 % vegan, free from GMOs, artificial colors, and preservatives, and it’s sweetened naturally with vegetable glycerin—so you get a pleasant, slightly sweet taste without any added sugar.
The glycerin base also makes the drops easy on the stomach and suitable for those avoiding alcohol. With 168 servings per 4 fl oz. bottle, a twice‑daily routine provides an 84‑day supply, offering long‑term support without frequent repurchasing.
Pros
- Strong 685 mg herb dose per serving
- Vegan, non‑GMO, no artificial additives
- Alcohol‑free glycerin base for easy digestion
- Naturally sweet taste, zero added sugar
- 84‑day supply reduces refill frequency
Cons
- May interact with certain medications
- Requires consistent twice‑daily dosing
- Not suitable for children without supervision
4. Toniiq St. John’s Wort Capsules
Toniiq 1,000 mg Ultra High Strength St. John’s Wort capsules deliver the most potent, bio‑available form of this classic herb. Each serving packs a 7:1 concentrated extract, providing 1,000 mg of premium, non‑GMO St. John’s Wort powder that’s ethically sourced and cultivated.
The formula is standardized to 0.3 % hypericin—the most studied compound for mood support—making it one of the highest‑concentration products on the market.
Quality is front‑and‑center: every batch is manufactured in a GMP‑certified U.S. facility, undergoes rigorous in‑house testing, and is verified by an independent third‑party lab for purity, potency, and the absence of contaminants.
The result is a highly purified, bioavailable supplement you can trust for consistent, effective results.
Pros
- 7:1 extract ratio for maximum potency
- Highest market concentration of hypericin (0.3 %)
- GMP‑certified U.S. manufacturing ensures safety
- Third‑party lab testing guarantees purity
- Non‑GMO, ethically sourced botanical ingredient
Cons
- May interact with certain medications
- Not suitable for pregnant or nursing women
- Large capsule size could be hard to swallow
3. Nature’s Way St. John’s Wort 700 mg 180 Caps
Nature’s Way St. John’s Wort is a plant‑based herbal supplement designed to help you maintain a positive outlook.
Each serving delivers a potent 700 mg of standardized St. John’s Wort across two capsules, and the recommended regimen is two capsules twice daily for at least two months to see optimal results.
The formula is completely gluten‑free and vegan, containing no wheat, corn, soy, dairy, gelatin, artificial colors, flavors, or preservatives. It also carries the Non‑GMO Project Verified seal, giving you confidence that the ingredients are sourced responsibly.
Packaged in a 180‑capsule bottle (packaging may vary), this supplement reflects Nature’s Way’s 50‑year commitment to harnessing nature’s solutions for everyday wellness.
Pros
- Supports a positive mental outlook naturally
- High‑potency 700 mg per two‑capsule dose
- Gluten‑free, vegan, and allergen‑free formula
- Non‑GMO Project Verified for purity
- Convenient 180‑capsule supply, two‑month starter
Cons
- Requires consistent twice‑daily dosing
- Benefits may take two months to appear
- Packaging variations could cause confusion
2. Nature’s Bounty St. John’s Wort 300mg Capsules
Nature’s Bounty St. John’s Wort 300mg Capsules is a popular herbal supplement formulated to support a balanced mood and emotional well-being. Each capsule contains high-quality St. John’s Wort extract, traditionally used to promote a calm and positive mindset.
This supplement is ideal for adults looking to support mental wellness as part of a healthy lifestyle. The formula is free from gluten, artificial colors, flavors, sweeteners, dairy, soy, and yeast, making it suitable for many dietary preferences.
Nature’s Bounty follows strict quality standards to ensure purity, potency, and consistency in every bottle. Easy-to-swallow capsules make daily supplementation simple and convenient.
Pros
- Supports emotional balance
- Trusted herbal ingredient
- Gluten-free formula
- No artificial additives
- Easy daily capsules
Cons
- Not for medical treatment
- Possible drug interactions
- Results may vary
1. Zazzee St. John’s Wort 20:1 Extract
Zazzee Extra Strength St. John’s Wort 20:1 Extract delivers a powerhouse dose of 8,000 mg per vegan capsule, standardized to a minimum 0.3 % hypericin—the active compound that drives the herb’s mood‑supporting benefits.
Each bottle contains 150 capsules, giving you a full five‑month supply without the need for double‑dosing that many competing brands require.
The 20:1 concentrated extract means you get the therapeutic potency of a much larger raw herb amount in a single pill, while the non‑GMO, all‑natural formula is free from sweeteners, artificial flavors, gluten, soy, dairy, and common allergens.
Produced in a U.S. GMP‑certified facility, this supplement meets strict quality standards, so you can trust the consistency and safety of every capsule.
Whether you’re looking to maintain emotional balance, support a healthy nervous system, or simply enjoy a premium, plant‑based supplement, Zazzee’s St. John’s Wort offers unmatched value and potency.
Pros
- 8,000 mg strength per capsule, 20:1 extract
- Minimum 0.3 % hypericin for high potency
- 150 capsules = five‑month supply, great value
- 100 % vegan, non‑GMO, allergen‑free formula
- Manufactured in U.S. GMP‑certified facility
Cons
- May be stronger than needed for beginners
- Not suitable for those on certain medications
- Requires consistent daily intake for best results
Frequently Asked Questions
What should I look for to identify the best St. John’s Wort supplement?
- Standardized extract: Choose a product that specifies a standardization to 0.3 % hypericin and 5 % hyperforin, which are the key active compounds.
- Third‑party testing: Look for seals from USP, NSF, or ConsumerLab confirming purity and potency.
- Dosage form: Capsules or tablets are most common; some people prefer liquid extracts for faster absorption.
- Ingredient list: The supplement should contain only St. John’s Wort extract and minimal fillers (e.g., rice flour, magnesium stearate).
How much St. John’s Wort should I take for mild to moderate mood support?
- The typical dose used in clinical studies is 300 mg of standardized extract three times daily (total 900 mg).
- Start with one capsule (300 mg) once a day and gradually increase to the full dose if tolerated.
- Always follow the manufacturer’s recommended dosage and consult a healthcare professional, especially if you are on other medications.
Are there any safety concerns or drug interactions with St. John’s Wort?
- Major drug interactions: St. John’s Wort can reduce the effectiveness of antidepressants, birth‑control pills, anticoagulants, HIV meds, and many others by inducing liver enzymes (CYP3A4).
- Side effects: Commonly mild and include gastrointestinal upset, dry mouth, dizziness, or photosensitivity (increased sun sensitivity).
Conclusion
Choosing the right St. John’s Wort supplement hinges on a blend of quality, transparency, and personal health needs. Prioritize formulations that use standardized extracts, reputable sourcing, and third‑party testing to ensure potency and safety.
Consider dosage flexibility, clear labeling, and any additional ingredients that support mood balance without compromising purity.
By weighing these factors alongside your own wellness goals and consulting a healthcare professional, you can confidently select a product that delivers consistent, reliable benefits.
Ultimately, the best supplement is the one that aligns with both scientific standards and your individual lifestyle, helping you maintain a brighter, more balanced outlook.
