Tributyrin is a powerful supplement known for supporting digestive health and promoting a balanced gut microbiome. As a triglyceride form of butyric acid, it helps nourish intestinal cells, reduce inflammation, and support overall gastrointestinal function.
Many people turn to tributyrin to improve digestion, enhance nutrient absorption, and maintain healthy bowel movements.
With numerous products available on the market, selecting a high-quality supplement can be challenging. Factors like purity, dosage, and formulation play a crucial role in effectiveness.
This guide highlights the top 10 best tributyrin supplements, providing options designed to optimize gut health and support overall wellness naturally.
10. Tributyrin-X Softgels
Tributyrin‑X delivers professional‑grade, 99.9 % pure liquid tributyrine – the most bioavailable form of butyrate on the market. Housed in tiny, odor‑free gel capsules, it slides down easily without the dreaded “burp‑back” many supplements cause.
Every softgel is free from additives, sterates, lactose, silicon dioxide, charcoal, fillers, GMO ingredients, gluten, and sugar, making it a clean, non‑inflammatory choice for anyone looking to restore gut balance.
Regular use supports normalized bowel movements, reduced bloating, leaky‑gut healing, and stronger tolerance to common food sensitivities. Beyond gut health, users report better sleep, more steady energy, decreased swelling, and a richer, more diverse microbiome.
Whether you’re battling occasional digestive upset or seeking a proactive boost to overall wellness, Tributyrin‑X offers a potent, pure postbiotic solution that fits seamlessly into any daily routine.
Pros
- Ultra‑pure liquid tributyrine for maximum absorption
- Odorless, burp‑free capsules easy to swallow
- No additives, fillers, or common allergens
- Supports leaky gut repair and regularity
- Enhances sleep, energy, and microbiome diversity
Cons
- Requires consistent daily dosing for results
- May be pricey compared to generic butyrate powders
- Not suitable for those with severe capsule swallowing issues
9. DEVA Tributyrin 500 MG Capsules
Experience gut‑health support the vegan way with DEVA’s Tributyrin Supplement. Each capsule delivers 500 mg of pure, plant‑derived tributyrin—the well‑researched precursor to butyric acid, a short‑chain fatty acid that fuels colon cells when good bacteria ferment fiber.
Formulated to reinforce the intestinal mucus barrier, this supplement helps maintain optimal water and sodium balance while promoting comfortable digestion.
The capsules are completely free of dairy, gluten, soy, wheat, salt, sugar, and yeast, and they carry the Vegan Society’s certified‑vegan seal.
With 90 capsules per bottle and a convenient pack of two, you have a 180‑day supply of gut‑friendly nutrition without any animal‑derived ingredients.
Pros
- 500 mg vegan tributyrin per capsule, potent dose
- Supports gut barrier and mucus layer integrity
- Gluten‑free, dairy‑free, soy‑free, allergen‑safe formula
- Certified vegan by the Vegan Society standards
- 180‑day supply in a convenient two‑bottle pack
Cons
- May cause mild digestive adjustment initially
- Not suitable for those avoiding all capsules
- Requires consistent daily intake for best results
8. Nature’s Bounty Tributyrin Capsules
Tributyrin Supplement delivers the next‑generation postbiotic you’ve been waiting for. By encapsulating butyrate in a triglyceride form, this formula travels past the stomach and small intestine, releasing the active compound right where it matters most—in the lower gut.
The result is a smoother digestive experience that helps restore the gut lining, reduces occasional bloating, and supports a balanced microbiome.
Unlike sodium butyrate, which is largely absorbed before reaching the colon, Tributyrin’s superior delivery ensures the gut barrier stays strong and the inflammatory response remains in check.
Whether you’re looking to repair a leaky gut or simply maintain long‑term digestive health, these 30 easy‑to‑swallow capsules fit seamlessly into any wellness routine.
Pros
- Superior gut‑line delivery beyond the small intestine
- Reduces bloating for a calmer stomach
- Supports strong gut barrier and integrity
- Promotes balanced microbiome and inflammation control
- Gentle, gradual absorption for sensitive users
Cons
- May require consistent daily intake for full benefits
- Not a substitute for medical treatment of serious gut disorders
- Slightly higher price than basic sodium butyrate options
7. Immortal Herbs Tributyrin 800mg Capsules
Immortal Herbs Tributyrin Supplement delivers a potent, 800 mg dose of standardized tributyrin (55 % active) in every serving—equating to 480 mg of pure postbiotic butyrate.
This advanced form is more stable and bio‑available than traditional sodium butyrate, ensuring consistent gut‑supporting benefits without the harsh taste.
Each vegan capsule is free from GMOs, gluten, and artificial additives, making it ideal for daily use. With 120 capsules per bottle and a recommended 2‑capsule daily regimen, you receive a full 60‑day supply of clean, science‑backed nutrition.
Manufactured in a GMP‑ and ISO‑certified facility, every batch undergoes rigorous testing for purity and potency. Immortal Herbs blends ancient healing wisdom with modern research, providing a high‑impact postbiotic that supports intestinal health, immune balance, and overall well‑being.
Pros
- High‑potency 800 mg tributyrin per serving
- 55 % standardized for reliable active content
- Stable, bioavailable alternative to sodium butyrate
- Vegan, non‑GMO, gluten‑free capsules
- 60‑day supply with rigorous GMP testing
Cons
- May be pricey for some budgets
- Requires two capsules daily for full effect
- Not suitable for those allergic to capsule gelatin (though vegan)
6. Healthy Gut Tributyrin-X 90 Softgels
Tributyrin‑X delivers the most bioavailable form of butyrate available on the market—a professional‑grade, 99.9 % pure liquid tributyrin packed into easy‑to‑swallow softgels. This postbiotic works from the inside out, supporting a healthy gut lining, normalizing bowel movements, and reducing bloating.
By strengthening the intestinal barrier it helps heal leaky gut and can lessen the impact of common food sensitivities. The odor‑free capsules eliminate the typical “burp‑up” of other butyrate products, making daily use pleasant and discreet.
Formulated without additives, sterates, lactose, silicon dioxide, charcoal, fillers, gluten, sugar, or GMOs, Tributyrin‑X is a clean, professional‑grade supplement that also promotes better sleep, more energy, and a more diverse microbiome.
Pros
- Ultra‑pure 99.9 % liquid tributyrin
- Odor‑free softgels, no burping
- No fillers, gluten‑free, non‑GMO
- Supports leaky gut healing and digestion
- Enhances sleep quality and daily energy
Cons
- May be pricey for some budgets
- Requires consistent daily intake for best results
- Not suitable for those with severe allergies to capsule ingredients
5. Designs for Health Tri-Butyrin Supreme 3-in-1 Tributyrin Supplement
Designed for anyone looking to close the gap between probiotics and a truly resilient gut, Designs for Health Tri‑Butyrin Supreme delivers a clinically‑backed, triple‑butyrate formula in an odor‑minimizing softgel.
Each capsule contains tributyrin—three butyrate molecules chemically bonded to glycerol—so the fatty acid reaches the colon intact, where it can nourish the epithelial lining, support a balanced microbiome, and help maintain gut permeability.
The post‑biotic approach complements pre‑ and probiotics, providing a direct source of butyrate that the body uses to fuel colon cells and modulate immune signaling.
Formulated without gluten and manufactured under strict purity standards, this supplement is trusted by functional‑medicine practitioners worldwide for its consistent potency and minimal scent.
Whether you’re managing occasional digestive discomfort, aiming to fortify your immune defenses, or simply seeking optimal gut health, Tri‑Butyrin Supreme offers a convenient, science‑driven solution.
Pros
- Triple‑butyrate delivery for maximum efficacy
- Odor‑minimizing softgels improve user experience
- Supports gut lining and immune function naturally
- Gluten‑free formulation meets strict dietary needs
- Clinically trusted by functional‑medicine professionals
Cons
- May cause mild gastrointestinal adjustment
- Requires consistent daily intake for benefits
- Not suitable for individuals with severe liver disease
4. Nature’s Bounty Tributyrin 800mg Supplement
Tributyrin Supplement for Gut & Immune 800 mg delivers a high‑potency, science‑backed blend designed to support digestive health and immune resilience.
Each serving supplies 800 mg of pure tributyrin—an efficiently absorbed form of butyric acid—paired with 10 billion CFU of probiotic cultures and 150 mg of prebiotic fiber.
Advanced microencapsulation technology shields the live bacteria and delicate nutrients, ensuring they survive stomach acidity and reach the intestines intact for maximum bioavailability.
The formula is further enriched with a synergistic quartet of botanical extracts: curcumin, black cumin seed oil, algal oil, and ginger extract.
Together they enhance antioxidant defenses, promote healthy inflammation responses, and complement the gut‑supporting action of tributyrin.
Unlike traditional dry‑filled capsules, these liquid‑filled capsules feel gentle on the stomach, dissolve quickly, and stay fresh behind a secure seal. The product is gluten‑free, non‑GMO, and manufactured in a GMP‑certified facility, making it a clean, convenient addition to daily wellness routines.
Pros
- High‑potency 800 mg tributyrin per dose
- Microencapsulation protects probiotics & prebiotics
- Liquid‑filled capsules absorb faster, gentler stomach
- Curcumin‑black cumin‑algal‑ginger synergy boosts immunity
- Gluten‑free, non‑GMO, GMP‑certified quality
Cons
- Requires consistent daily intake for best results
- May cause mild digestive adjustment initially
- Not suitable for those allergic to fish‑derived algal oil
3. CoreBiome Tributyrin Postbiotic Capsules
CoreBiome Tributyrin Postbiotic Supplement is a clinically‑tested, high‑bioavailability formula designed to nourish the gut from the inside out.
Unlike cheap, flash‑filled “postbiotic” pills, each capsule delivers patented CoreBiome™ Tributyrin (55 % extract) that has been shown in human studies to boost beneficial butyrate‑producing bacteria such as Faecalibacterium prausnitzii and Anaerostipes.
The tributyrin molecule bypasses the stomach and releases its active butyrate directly in the colon—where sodium butyrate often fails—supporting a balanced microbiome, stronger intestinal walls, and overall immune health.
The supplement is free from the top eight allergens (soy, milk, egg, shellfish, corn, wheat, peanuts, gluten) and contains no preservatives. It’s manufactured in a GMP‑certified U.S. facility, meeting the highest quality standards.
Plus, every purchase triggers a 1‑for‑1 donation through Vitamin Angels, providing a year’s worth of vitamins to a child at risk of malnutrition—over 3 million children helped to date.
Pros
- Clinically proven boost to butyrate‑producing microbes
- Superior colon delivery versus sodium butyrate
- Allergen‑free, gluten‑free, preservative‑free formula
- GMP‑certified U.S. manufacturing ensures purity
- 1‑for‑1 donation supports global child nutrition
Cons
- Requires consistent daily intake for best results
- May cause mild gas during initial adaptation
- Not suitable for those with rare tributyrin hypersensitivity
2. DEVA Tributyrin, 90 Count
DEVA Vegan Tributyrin Supplement delivers a potent, plant‑based source of butyrate — the short‑chain fatty acid that fuels colon cells and supports a healthy gut barrier.
Each capsule provides 500 mg of pure, vegan‑certified tributyrin, a well‑studied precursor that your gut microbes convert into butyric acid when they break down dietary fiber.
Formulated without dairy, gluten, soy, salt, sugar, wheat, or yeast, these capsules are gentle on sensitive stomachs while helping maintain the intestinal mucus layer, water and sodium absorption, and overall bowel function.
Ideal for anyone dealing with leaky gut, digestive discomfort, or looking to boost gut health naturally, DEVA’s non‑animal sourcing and Vegan Society certification ensure the product aligns with ethical and dietary preferences.
Pros
- 100 % vegan, certified by Vegan Society
- High‑potency 500 mg tributyrin per capsule
- Supports gut barrier and mucus layer
- Gluten‑free, dairy‑free, allergen‑friendly formula
- Promotes healthy digestion and bowel function
Cons
- May cause mild gas initially
- Requires consistent daily intake for best results
- Not a standalone cure for severe gut disorders
1. Tributyrin 800mg – Liquid-Filled Complex
Experience gut‑health support like never before with our Tributyrin Supplement for Gut & Immune. Each serving delivers a potent 800 mg of tributyrin—a scientifically‑backed form of butyric acid that helps maintain intestinal lining integrity and modulate immune response.
The formula is enhanced by microencapsulation technology, which shields the active ingredients and releases them precisely where they’re needed, boosting absorption and preserving probiotic viability.
Inside each capsule you’ll find a synergistic blend of 10 billion CFU of probiotics and 150 mg of prebiotic fiber, working together to promote a balanced microbiome.
Added botanical extracts—curcumin, black‑cumin seed oil, algal oil, and ginger—contribute anti‑inflammatory and antioxidant benefits.
Unlike traditional dry‑filled tablets, our liquid‑filled capsules are easy on the stomach, absorb quickly, and stay fresh behind a secure seal. Gluten‑free and crafted for daily use, this advanced complex is designed for anyone looking to optimize digestion, immunity, and overall vitality.
Pros
- High‑potency 800 mg tributyrin per serving
- Microencapsulation ensures targeted gut delivery
- 10 billion CFU probiotics with 150 mg prebiotic fiber
- Botanical blend adds anti‑inflammatory support
- Liquid‑filled capsules absorb faster, gentler stomach
Cons
- May be pricier than basic probiotic pills
- Requires consistent daily intake for best results
- Not suitable for individuals with severe allergies to seed oils
Frequently Asked Questions
What is tributyn and how does it differ from regular butyrate?
Tributyn is a triglyceride that contains three molecules of butyric acid bound to a glycerol backbone. When ingested, digestive enzymes release free butyrate in the small intestine, allowing it to be absorbed more efficiently than free‑form butyrate powders, which can be degraded by stomach acid. This makes tributyn a more stable and bioavailable source of the beneficial short‑chain fatty acid.
How do I pick the best tributyn supplement?
- Purity & sourcing – Look for products that list “100 % pure tributyn” and are derived from non‑GMO, grass‑fed butter or microbial fermentation.
- Third‑party testing – Certifications from labs such as NSF, USP, or ConsumerLab confirm potency and the absence of contaminants.
- Dosage form – Softgels are convenient and protect the oil from oxidation; powders can be mixed into smoothies if you prefer.
- Added ingredients – Avoid blends with unnecessary fillers, artificial colors, or excessive added fats that could dilute the effective dose.
Conclusion
Choosing the right tributyrin supplement ultimately hinges on balancing potency, purity, and value while aligning with your personal health goals.
High‑quality formulas deliver reliable concentrations of butyric acid, supporting gut integrity, metabolic function, and immune balance without unnecessary fillers or artificial additives.
Look for products that are third‑party tested, transparently labeled, and sourced from reputable manufacturers to ensure safety and efficacy. Consistent dosing, ideally taken with meals, maximizes absorption and helps maintain steady levels in the digestive tract.
By prioritizing these criteria, you can confidently integrate tributyrin into your regimen and reap its scientifically supported benefits for overall wellness.
